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- December 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: Beyond Traditional X-rays | Note on the Development of Computed Tomography (through the 1990s)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Beyond Traditional X-rays | Note on the Development of Computed Tomography (through the 1990s)." Harvard Business School Technical Note 321-055, December 2020. (Revised May 2021.)
- December 2020 (Revised April 2021)
- Technical Note
Tales of Life-changing Innovations: Controversial Blockbuster | Note on the Development of Prozac (through 1999)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Controversial Blockbuster | Note on the Development of Prozac (through 1999)." Harvard Business School Technical Note 321-057, December 2020. (Revised April 2021.)
- December 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: High Quality and Radiation Free | Note on the Development of Magnetic Resonance Imaging (through the 1990s)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: High Quality and Radiation Free | Note on the Development of Magnetic Resonance Imaging (through the 1990s)." Harvard Business School Technical Note 321-056, December 2020. (Revised May 2021.)
- December 2020 (Revised April 2021)
- Technical Note
Tales of Life-changing Innovations: Without Cutting In | Note on the Development of Endoscopy (through the 1990s)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Without Cutting In | Note on the Development of Endoscopy (through the 1990s)." Harvard Business School Technical Note 321-061, December 2020. (Revised April 2021.)
- November 2020 (Revised April 2021)
- Technical Note
Tales of Life-changing Innovations: Containing a Fearsome Pandemic | Note on the Development of HIV/AIDS Controls, Tests, and Treatments (through 2000)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Containing a Fearsome Pandemic | Note on the Development of HIV/AIDS Controls, Tests, and Treatments (through 2000)." Harvard Business School Technical Note 321-052, November 2020. (Revised April 2021.)
- November 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: Early Detection, Precise Diagnoses | Note on the Development of Mammography (though 2000)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Early Detection, Precise Diagnoses | Note on the Development of Mammography (though 2000)." Harvard Business School Technical Note 321-064, November 2020. (Revised May 2021.)
- November 2020 (Revised April 2021)
- Technical Note
Tales of Life-changing Innovations: Eradicating H-Pylori Infections | Note on the Development of Antibiotic Treatments for Ulcers
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Eradicating H-Pylori Infections | Note on the Development of Antibiotic Treatments for Ulcers." Harvard Business School Technical Note 321-053, November 2020. (Revised April 2021.)
- November 2020 (Revised April 2021)
- Technical Note
Tales of Life-Changing Innovations: Fighting Hospital Infections | Note on the Development of Cephalosporins (through 2000)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-Changing Innovations: Fighting Hospital Infections | Note on the Development of Cephalosporins (through 2000)." Harvard Business School Technical Note 321-059, November 2020. (Revised April 2021.)
- November 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: Reducing Breast Cancer Risks | Note on the Development of Tamoxifen (through 1999)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Reducing Breast Cancer Risks | Note on the Development of Tamoxifen (through 1999)." Harvard Business School Technical Note 321-058, November 2020. (Revised May 2021.)
- November 2020 (Revised May 2021)
- Technical Note
Tales of Life-changing Innovations: Safe and Cheap Diagnostics | Note on the Development of Ultrasound Scanning (through 2000)
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Tales of Life-changing Innovations: Safe and Cheap Diagnostics | Note on the Development of Ultrasound Scanning (through 2000)." Harvard Business School Technical Note 321-054, November 2020. (Revised May 2021.)
- 2021
- Working Paper
Cephalosporins: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant Datar and Katherine Stebbins
Our case history describes the development of three generations of cephalosporins—antibiotics that have significantly reduced hospital infections. After providing an overview of antibiotic development and its challenges we describe how: 1) Early (pre-cephalosporin)...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant Datar, and Katherine Stebbins. "Cephalosporins: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-133, July 2020. (Revised May 2021.)
- 2021
- Working Paper
SSRIs and Non-SSRIs (through 1999): Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
Our case history describes the development of Prozac, a blockbuster drug that transformed the treatment of depression – and became a cultural phenomenon in the United States. Specifically, we chronicle the: 1) prior treatments for depression and the research that...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "SSRIs and Non-SSRIs (through 1999): Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-135, July 2020. (Revised June 2021.)
- 2021
- Working Paper
Computed Tomography: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how Computed Tomography (CT) scanners—that combine x-rays and computers to image soft tissues of the brain and other organs—have become a widely used diagnostic tool. Specifically, we chronicle the: 1) the initial development of CT technology and markets...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Computed Tomography: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-004, July 2019. (Revised May 2021.)
- 2021
- Working Paper
Development of Ultrasound Scanning: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how efforts on multiple fronts, including advocacy, training and technological development made ultrasound the second most used diagnostic imaging technology (after X-rays). Specifically, we chronicle: 1) ultrasound’s development and introduction in the...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Development of Ultrasound Scanning: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-003, July 2019. (Revised May 2021.)
- 2021
- Working Paper
Eradicating Helicobacter Pylori Infections to Treat Ulcers: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how a chance discovery of bacteria that infect stomach linings completely changed how physicians treat ulcers. Specifically, we chronicle how: 1) two Australian physicians brought the bacterial infection to the world’s attention and challenged the...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Eradicating Helicobacter Pylori Infections to Treat Ulcers: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-006, July 2019. (Revised May 2021.)
- 2021
- Working Paper
Gastrointestinal Endoscopy: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how endoscopy transformed the diagnosis of ulcers, cancerous polyps and other diseases of the alimentary canal and enabled “minimally invasive” surgeries to treat such diseases. Specifically, we chronicle how: 1) flexible glass fiber instruments in the...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Gastrointestinal Endoscopy: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-005, July 2019. (Revised May 2021.)
- 2021
- Working Paper
HIV Tests and AIDS Treatments: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how a diverse cast of characters including public health organizations, research laboratories, for-profit health care companies, activists and regulators, rolled back the outbreak of HIV/AIDS in just fifteen years. Moreover, as the case history shows, a...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "HIV Tests and AIDS Treatments: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-007, July 2019. (Revised May 2021.)
- 2021
- Working Paper
Magnetic Resonance Imaging: Case Histories of Significant Medical Advances
By: Srikant M. Datar, Amar Bhidé and Katherine Stebbins
We describe how and why Magnetic Resource Imaging (MRI) came to complement – and partially replace -- computed tomography (CT) imaging of soft tissue. Specifically we chronicle: 1) the development of foundational techniques and prototypes (through the 1970s); 2)...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Datar, Srikant M., Amar Bhidé, and Katherine Stebbins. "Magnetic Resonance Imaging: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-001, July 2019. (Revised June 2021.)
- 2021
- Working Paper
Mammography: Case Histories of Significant Medical Advances
By: Amar Bhidé, Srikant M. Datar and Katherine Stebbins
We describe how the development of x-ray-based techniques and equipment (“mammography”) lead to widespread screening for breast cancer and enabled “minimally invasive” biopsies of breast tumors. Specifically, we chronicle how: 1) the protocols and equipment, developed...
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Keywords:
Health Care and Treatment;
Technological Innovation;
Innovation Strategy;
Technology Adoption;
Collaborative Innovation and Invention;
Innovation and Invention;
Governing Rules, Regulations, and Reforms
Bhidé, Amar, Srikant M. Datar, and Katherine Stebbins. "Mammography: Case Histories of Significant Medical Advances." Harvard Business School Working Paper, No. 20-002, July 2019. (Revised May 2021.)